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Introducing Epicutis: Clinical Calm for Sensitive, Stressed, and Aging Skin



At [ Skin + Tonic ], we’re incredibly selective about what earns space on our shelves—and more importantly, on your skin.


So when we bring in a new brand, you can trust it’s backed by science, clinically clean, and aligned with our deeper philosophy:

Beauty begins with barrier health.


This season, we’re thrilled to introduce Epicutis—a medical-grade skincare line formulated by scientists, trusted by physicians, and designed for sensitive, inflamed, or post-procedure skin.


Whether you’re dealing with acne, rosacea, aging, or over-treated skin, Epicutis delivers calm, clarity, and clinical results—without compromise.




✧ Hero Ingredient Spotlight: TSC



The signature molecule behind Epicutis is TSC (Tetramethylhexyl Succinoyl Cysteine)—a patented, lipid-stable compound that:


  • Reduces inflammation at the genetic level

  • Deactivates pro-inflammatory pathways like NF-κB

  • Protects collagen from MMP degradation

  • Reinforces skin barrier function



Unlike many anti-inflammatories, TSC is small enough to penetrate but gentle enough to use post-procedure (think microneedling, lasers, or peels). It’s the kind of “quiet science” we love—deep work beneath the surface, no irritation on top.




✧ Hinoki Oil: Nature’s Antiseptic, Reimagined



Epicutis also utilizes Hinoki oil, extracted from the Japanese cypress tree. Traditionally used in spiritual rituals and healing baths, Hinoki is:


  • Antimicrobial

  • Anti-inflammatory

  • Calming to both the skin and the senses



It helps reduce redness, balance sebum, and support your microbiome—making it ideal for inflamed or reactive skin types.


The scent alone is grounding, herbal, and clean—zero synthetic fragrance, just plant-based purity.




✧ NEW: Epicutis Oil-Free SPF — A Sunscreen You’ll Actually Love



The latest release from Epicutis is their Oil-Free SPF 50 Sunscreen—a non-nano zinc oxide formula that blends seamlessly and wears like silk.


✔️ No white cast

✔️ No pilling under makeup

✔️ Reef-safe + fragrance-free

✔️ Formulated with TSC to calm while it protects


This isn’t just sun protection—it’s barrier therapy with broad-spectrum coverage. Whether you’ve just had a peel or you’re on your third cup of coffee and headed to Pilates, this SPF fits effortlessly into your day.




✧ Who It’s For:



Epicutis is especially suited for:


  • Sensitive or inflamed skin

  • Compromised skin barrier (from over-exfoliation, acne meds, etc.)

  • Post-treatment recovery

  • Patients with melasma, rosacea, or redness-prone skin

  • Anyone ready to simplify and elevate their skincare ritual



Absolutely! Here are the key studies supporting TSC (Tetramethylhexadecenyl Succinoyl Cysteine), summarized clearly:




Clinical & In-Vitro Evidence for TSC



  1. Pilot Clinical Study (2025)

    A human trial published in the Journal of Cosmetic Dermatology showed that applying 0.5% TSC alongside 0.2% tretinoin significantly reduced erythema (redness) and dryness compared to tretinoin alone—without adverse events  .

  2. In Vitro Cellular Research


    • Keratinocytes, PBMCs, and Endothelial Cells: TSC effectively blocked inflammatory cytokines like IL‑6, IL‑8, IL‑4, and IL‑17 when those cells were exposed to irritants such as UVB, TPA, nickel, or T-cell receptor activation  .

    • Antimicrobial Action: TSC inhibited growth of Streptococcus pyogenes (and has been previously shown to affect Propionibacterium acnes)—adding antibacterial support to its anti-inflammatory profile   .






Summary Table: TSC’s Evidence at a Glance


Bioactivity

Evidence

Reduces retinoid irritation

Pilot clinical study in humans 

Anti-inflammatory effects

In vitro: inhibits UVB/TPA/Nickel/TCR-induced cytokine release    

Antimicrobial activity

Inhibits skin pathogens like S. pyogenes (and P. acnes)   



In short, TSC is more than a marketing term—it’s a well-researched lipid-based molecule with clinically demonstrated benefits, especially for calming retinoid-induced irritation, cellular inflammation, and bacterial challenges.




✧ Why We Love It at [ Skin + Tonic ]:



Because it’s skincare with intent.

Because it’s ingredient-conscious without sacrificing efficacy.

Because our patients are ready for less fluff, more function.


Epicutis is what we reach for when your skin is talking back—and you need it to listen, heal, and radiate again.




✧ Try It in Your Next Ritual



We’ll be integrating Epicutis into select facials and post-procedure protocols—including microneedling, PRF, and exosome therapy.


You can also shop the line in-clinic and take home what your skin actually needs.


📍 Visit us at 3511 Volunteer Blvd. #120, Henderson, NV

📞 (702) 854-6654



Because healing is where the glow begins.

 
 
 

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